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About this article Cite this article Petersen, J., Finan, B., Johansen, V.B.I

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It can extract intracellular glutamate and absorb extracellular cystine to reduce it to cysteine, thereby participating in GSH synthesis ( Iron Metabolic Pathway Iron is essential for homeostasis in the human body, with excess iron or its dysregulation associated with the pathological progression of various diseases ( 2+ reduces oxygen to form superoxide radicals, which cause lipid peroxidation through the Fenton reaction and induce ferroptosis in cells ( Lipid Metabolic Pathway Ferroptosis is emerging as a new form of iron-dependent regulated cell death (RCD), which is driven by excessive lipid peroxidation inducers in recent years

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