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In NDDs, mitochondrial dysfunction is closely intertwined with diets and other environmental stressors, mediated by transcription factors such as heat shock response factors [83]

Dif F, Wu YZ, Burgel PR et al (2010) Critical role of cytosolic phospholipase A2 in bronchial mucus hypersecretion in CFTR-deficient mice

In chronic illness, this pathway often becomes overwhelmed or suppressed

Nevertheless, this investigation presents some limitations

Although pannexin channels are primarily known for mediating ATP release, some experimental evidence suggests they may also participate in lactate flux under specific non-homeostatic conditions, though this remains speculative and requires further validation [14]