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J Cardiovasc Pharmacol 35: 37-44, 2000 Diamond BJ, Shiflett SC, Feiwel N, Matheis RJ, Noskin O, Richards JA, Schoenberger NE: Ginkgo biloba extract: Mechanisms and clinical indications

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For instance, the secretion of interferon gamma (IFN-) by CD8+ T cells has been shown to down-regulate the expression of SLC3A2 and SLC7A11 in tumor cells, leading to a disruption in cystine uptake ( Myeloid-derived suppressor cells (MDSCs) express the transporter SLC7A11, which selectively transports cystathionine but does not export cysteine

2PG can be toxic and provides a metabolic signal that falsely indicates carbon limitation