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Q: Can it be combined with other therapies

Demethoxycurcumin, bis-demethoxycurcumin, and curcumin are the primary compounds responsible for the biological activity of the rhizomes (54)

Overall they were mild or moderate and only a small proportion of patients had to discontinue the treatment.14 Given these results, mannitol was also tested on non-CF BE and even though the first studies were carried out on small groups of patients, during short periods of time and mostly relating to non-clinical issues, they showed promising results of its use in this patient population.11 An open-label study of mannitol (400mg), carried out on 9 patients with BE, once daily, during a 12-day period documented a highly significant improvement in quality of life, which is assessed by St George's Respiratory Questionnaire (SGRQ), and maintained for 610 days after cessation of treatment

Retrieved 23 February 2014

Hypermethylation of the transporter 1 ATP-binding cassette subfamily B member (TAP1) has been shown to suppress TAP1 expression in immunoreactive cancer stem cells (CSCs) within murine models of breast carcinoma, these CSCs manifest a downregulation in the expression of transporter associated with antigen processing genes and co-stimulatory molecules, thereby reducing their sensitivity to T-cell-mediated immune surveillance and potentially culminating in immunotherapy resistance