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According to the National Institutes of Health Office of Dietary Supplements, an estimated 6% of adults under 60 in the United States are B12 deficient, with the prevalence rising to nearly 20% in adults over 60

10.3389/fphar.2021.719880 34 LuoL

Mitochondrial dysfunction is a common feature of neurodegenerative diseases, exacerbating ROS overproduction [67,68,87]

Effect of 12 months of testosterone replacement therapy on metabolic syndrome components in hypogonadal men: data from the Testim Registry in the US (TRiUS)

As mentioned above, the nanocarriers can enter the body to achieve therapeutic effects by ingestion, inhalation, injection, and skin absorption