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Moreover, oxidative stress causes an increase in O2 concentrations, which triggers the Haber-Weiss reaction and excessive production of the harmful hydroxyl radical (OH )

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Importantly, as shown in the first row, LASSS supplementation effectively prevented an increase in the nitration level of ECM-HGF, whereas GSSSG did not demonstrate efficacy, inconsistent with its potent potential shown in in vitro experiments described earlier (see Figure 1b)