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One study shows that there is a temporal variation in the concentration of the hormone prolactin, with the concentration being highest in the early morning (between 02.01 and 06.00 h)

J Mol Neurosci 27:347354 Goma AA, Salama AR, Tohamy HG, Rashed RR, Shukry M, El-Kazaz SE (2024) Examining the influence of zinc oxide nanoparticles and bulk zinc oxide on rat brain functions: a comprehensive neurobehavioral, antioxidant, gene expression, and histopathological investigation

Another promising strategy is immunotherapy targeting -synuclein [181, 182]

Furthermore, Tan and colleagues identified five regions mapped into MutL homolog 1 ( MLH1 ) promoter (A, B, C, D, and E) as prognostic biomarkers for Chinese CRC patients [167]