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Determination of initial turnover number The initial turnover rates were determined in PBS at pH 7.4 (8 g l 1 NaCl (Labkem, SOCH-00T), 1.44 g l 1 Na 2 HPO 4 (Supelco, 1.06586), 0.2 g l 1 KCl (Panreac, 131494) and 0.24 g l 1 KH 2 PO 4 (Fisher Scientific, BP362)) using ABTS (1 mM), DMP (5 mM), guaiacol (50 mM), sinapic acid (0.35 mM) or p -coumaric acid (0.1 mM) as substrate

Chem., 54: 810-817

Downregulation of GPX4 could also play a role in LBP and arthritic pain

intracellular and extracellular water (ICW% and ECW%) and skeletal muscle mass (SMM%)

The SURMOUNT-1 trial showed meaningful weight loss at every dose level, with 5mg producing an average 15% body weight reduction over 72 weeks