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While glycine has been shown to promote MM proliferation through glutathione synthesis (43, 44), our study found that glycine synergizes with pomalidomide to promote apoptosis and suppress proliferation in MM cells

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It has been also revealed that low-dose ursodeoxycholic acid (UDCA) blocks the production of cancer induced reactive oxygen species through the PKC signaling pathway, thereby inhibiting transcription factors AP-1 and NF- B, leading to the expression of pro-inflammatory cytokine TNF- and reducing the consumption of cachexia (e.g., fat and skeletal muscle tissue loss) (Tschirner et al., 2012)