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Jko et al., 2017) and for poly(ADP-ribose) polymerases (PARPs), a family of proteins essential for repairing DNA damaged by ROS (Shen et al., 2015) (Figure 2)

PMCID: PMC7651839

Muscle Growth and Strength Gains: Promotes significant lean muscle mass accrual and increased strength, particularly when combined with resistance training

Moreover, several potential target proteins of DZXI related to cell signaling and synaptic chemical transmission, including PDE10A, PRKCG, and GRIA1, were predicted to have a high binding affinity to DZXI main compounds

These findings position creatine not solely as a metabolic buffer, but as an active signaling modulator of mitochondrial cell death pathways