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They are a natural byproduct of metabolism or caused by exposure to toxins in the environment such as tobacco smoke, UV light, and alcohol

4.2 Unconventional T cells as potential regulators of hepatic fibrosis Unconventional T cells constitute a functionally distinct group with a unique capacity to recognize non-peptidic antigens

doi: 10.1016/j.jns.2007.05.007 16 BerglesD

In contrast, in ethanol-exposed Grx1 -deficient mice, accumulation of FAS-SSG drives hepatocyte apoptosis through dysregulation of NF-B and AKT serine/threonine kinase 1 (AKT1) signaling 47

Extrafollicular IgD-CD27-CXCR5-CD11c- DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19