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If the window is kept open too long (beyond 6-8 weeks), the fibroblasts may become exhausted

Letrozole ionizes in both positive and negative ionization modes, while anastrozole undergoes only positive ionization

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In the multivariate Cox regression analyses, crude favorable prognostic factors included a good ECOG-PS before pemetrexed exposure, BMI 20.66, FA level 5.55 ng/mL before premedication, higher serum RBP level before pemetrexed treatment, SI G) (Supplementary Table S5(a))