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Vitamin A and its metabolites and related receptors play a key regulatory role in HSCs activation

doi: 10.1016/j.msard.2019.02.027 108

however, COWS was similar between the groups across the measured time-points

The published thresholds for ELF (9.8 and 11.3) and FIB4 (1.3 and 3.25) for advanced fibrosis were validated for their ability to predict both all LRE and LRE related to portal hypertension (PHTN-LRE)

PATHOPHYSIOLOGY The pathophysiology of hyperbilirubinemia in GS is multifactorial[11,12], involving disruptions in bilirubin production, hepatic uptake glucuronidation, and transport, all influenced by genetic factors (Figure 1)