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Proposed explanations include: Tissue retention of peptide or active metabolites Persistent activation of signaling cascades beyond peptide clearance Potential for active metabolites with prolonged tissue residence Excretion Pathways Limited data on elimination routes indicates: Likely renal excretion of peptide fragments based on molecular weight and water solubility Potential hepatic contribution to metabolite clearance No evidence of accumulation in chronic dosing studies in rats and monkeys Degradation products eliminated without evidence of toxic metabolite formation The dramatic disconnect between three-minute plasma half-life and prolonged metabolic effects remains one of the most intriguing and poorly understood aspects of AOD-9604 pharmacology, requiring further mechanistic investigation

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doi: 10.3389/fphar.2014.00280 Received 01 October 2014 Accepted 02 December 2014 Published 18 December 2014 Volume 5 - 2014 Edited by Dominique Massotte, Institut des Neurosciences Cellulaires et Intgratives, France Reviewed by Chris Bailey, University of Bath, UK

For a broader foundation on how these molecules actually signal, How Peptides Work in the Body and 7 Types of Therapeutic Peptides cover the cell biology in accessible terms

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