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5.1 Iron chelators and iron modifiers Iron chelators and modifiers effectively inhibit cellular ferroptosis by regulating the expression and activity of iron transporters and storage proteins, including transferrin and its receptor (TfR1), ceruloplasmin, ferroportin, divalent metal transporter 1 (DMT1), and other membrane iron transport proteins (24, 26)

(see Figure

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Compounds such as erastin and sulfasalazine, which inhibit system Xc , reduce cysteine availability, compromise GSH synthesis, and decrease GPX4 activity, thereby triggering ferroptosis (258)

This means that instead of considering the H 2 O 2 molecules as being presented individually and in rapid succession to the active sites, it is necessary to consider the whole network of nH 2 O 2 molecules hydrogen bonded to water and each other, spreading out from the enzyme