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The two most important adaptations are increased emphasis on resistance training and strategic use of high-intensity intervals

The dysregulation of GSH expression strongly correlates with onset and progression of numerous types of disease, including tumors (4), liver disease (5), diabetes (6) and neurodegenerative disease (7,8)

This research was funded by the National Natural Science Foundation of China (grant number 82104766), the Hunan Provincial Natural Science Foundation (grant numbers 2024JJ5313 and 2025JJ80981), the Health China-Buchang Zhiyuan Heart and Brain Health Public Welfare Project (grant number HIGHER2023041), and the Hunan University of Chinese Medicine Graduate Innovation Project (grant number 2024CX114)

To identify genes differentially expressed, the transcript counts were analyzed using DESeq2, and genes with false discovery rateadjusted p values below 0.05 and log2(fold change) above 2 or below -2 were identified

One factor that may have contributed to such a result in patients with HFrEF is the increased heart rate caused by GLP-1RAs [21]