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Access this article Similar content being viewed by others References Meister (1983) Selective modification of glutathione metabolism

Furthermore, although iron accumulation and lipid peroxidation are unique intermediate events in the onset of ferroptosis, they are not the ultimate executors

There is an interesting parallel here because these three molecules, which were initially thought to be exclusively toxic, may in fact represent key regulators for various biological processes and in particular for signaling purposes, considering their relative stability, their capacity to diffuse across membranes (NO) and H 2 S are gases and the uncharged H 2 O 2 is channeled via aquaporins) and their propensity to react with thiolates ( H 2 O 2 -MEDIATED MODIFICATION OF PROTEIN THIOLS With methionines, cysteines are the most H 2 O 2 -sensitive residues

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the pairs of enantiomers e.g., (S,S)/(R,R) the stereoisomers which are not mirror-images e.g., (S,S) and (R,S) are diastereomers