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It activates a variety of downstream target proteins that regulate cellular functions, and malfunctions in its activation are associated with the onset of a variety of diseases, including cancer, inflammation, metabolic disease, and cardiovascular disease

Y.WuJ.et al (2018b)

[DOI] [PubMed] [Google Scholar] 144.Soga T., Baran R., Suematsu M., Ueno Y., Ikeda S., Sakurakawa T., Kakazu Y., Ishikawa T., Robert M., Nishioka T., et al

Stereoselective reduction of ketone (2 R ,1 S )- 28 gave hydroxyaziridine 29 as the major (10:1) product which, after the protection of the hydroxy group, was subjected to the regioselective aziridine ring opening, catalytic removal of the chiral auxiliary with simultaneous formation of a N -Boc derivative 30