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Increasing evidence shows that the circadian rhythm plays a crucial role in various aspects of atherosclerosis, such as glucose metabolism, lipid metabolism, dysfunction of endothelial cells, the phenotype of vascular smooth muscle cells, and immune inflammatory responses [170]

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These scenarios may represent (a) false negative mutation analysis, (b) wrong diagnosis, or (c) mosaicism and other rare genetic aberrations

Li J, Lu L, Liu L, Ren X, Chen J, Yin X, et al