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Groups at higher risk of deficiency include older adults (due to reduced stomach acid production), people following vegan or strict vegetarian diets (as B12 is naturally found almost exclusively in animal products), individuals with pernicious anaemia or other malabsorption conditions, those taking certain medications such as metformin or proton pump inhibitors long-term, and people with significant nitrous oxide exposure (including recreational use), which can inactivate B12 in the body

It's worth noting that comparable work has been done with other peptides in equine musculoskeletal contexts

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Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging An effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation

In vitro pNPG processing assay The standard substrate p -nitrophenyl--D-glucuronide ( p NPG) was purchased as a solid (Sigma Aldrich) and resuspended in water to a concentration of 100 mM