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Additionally, ketamine activates the NLRP3 inflammasome, inducing caspase-1 activation and neuronal pyroptosis, further contributing to neuroinflammation in regions, such as the hippocampus and prefrontal cortex (Zhang et al., 2021)

Also observed was a thickened perineurium, an epineurium with abundant angiogenesis at the site of suture, and foreign body giant cells without granulomas, with an inflammatory infiltrate of lymphocytes

Cell 74 , 185195 (1993)

Conclusion: The findings highlight the significant role of MES-D in optimizing medical therapy, especially for atherosclerosis and cardiac embolic sources