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doi: 10.3389/fphar.2025.1490480 Received 03 September 2024 Accepted 01 April 2025 Published 16 April 2025 Volume 16 - 2025 Edited by Jae-hyeon Park, National Institute on Aging (NIH), United States Reviewed by Rajbir Singh, Patanjali Research Institute, India Naveen Sharma, Chung-Ang University, Republic of Korea Updates Copyright 2025 Wang, Wei, Chen and Chen

Elimination is achieved by means of a mobile phase, typically combination of water and organic solvents (such as acetonitrile or methanol) are sprayed onto the column in the form of gradient, such as 95:5 aqueous: organic, for example and gradually increasing the organic phase until the elution buffer is 5:95 organic: aqueous)

These tumor-associated metabolites are well reflected in the blood

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