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**BPC-157, a synthetic gastric pentadecapeptide studied primarily in animal models for tissue repair, gut healing, and anti-inflammatory effects, remains unapproved by the FDA as a finished drug with only limited small-scale human data available.** It was placed in Category 2 in 2023 due to concerns over immunogenicity, peptide impurities, and insufficient safety information for compounding under Section 503A

Primary Handling Editor: Christoph Schmitt, in collaboration with the Nature Metabolism team

Goal: Support satiety, reduce food intake, and promote weight management over time [2] [4]

Here are some of the most notable findings from studies conducted to date

Knee pain and mobility impairments: meniscal and articular cartilage lesions, revision 2018