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Methylglyoxal induces reactive oxygen species formation The entanglement of the MGO detoxification pathway with the redox status, through affecting GSH availability and glyoxalase efficiency as explained prior, has implications for the ROS balance in BMECs exposed to MGO

[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Chang AL, Miska J, Wainwright DA, et al

Before taking this medicine, tell your doctor if you have any other health conditions like kidney or liver diseases as a dose adjustment may be required

However, the most specific origin of ROS for melanocytes is processes related to melanin synthesis/metabolism 52

Excessive ROS, generated during oxidative phosphorylation, ischemia-reperfusion injury, and systemic inflammation cause extensive damage to lipids, proteins, and DNA