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It is found in practically every compartment of plant cells, including the chloroplasts, apoplast, mitochondria, cytosol, vacuole, peroxisomes, and endoplasmic reticulum, and predominantly in mitochondria in animal cells [18,24]

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These -cell characteristics make them vulnerable to destruction, and this is exacerbated in the pathogenic conditions of T1D and T2D, in which there are increased levels of pro-inflammatory cytokines, reactive oxygen species (ROS) and nitric oxide (NO), which are especially detrimental since -cells have limited antioxidant defense capabilities (42, 43), and are highly sensitive to cytokine mediated damage