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doi: 10.1038/s41598-017-11049-8 56 PanatierA.TheodosisD

SEI can improve the progression of AD through suppressing the NF-B activity, and thereby attenuating the production of inflammatory cytokines, oxidative stress, and apoptosis in endothelial cells (191)

Notably, the number of TUNEL-positive neurons, indicating DNA fragmentation and apoptosis, was also significantly decreased

Cumene hydroperoxide concentration is also increased from 12 mM up to 60 mM so that lipid peroxidation is increased and GP activity therefore is limited only by GP levels in RBC membrane preparations

An example of combination therapy includes delta-tocotrienol with cisplatin where the combination resulted in downregulation of Notch-1 via inhibition of NFkB signaling pathways resulting in controlling non-small cell lung cancer, while reducing the effective dose of cisplatin [56] suggesting that effective treatment can be achieved with reduced side effects and toxicity of cisplatin