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All reported side effects were mild to moderate in severity, with no severe treatment-related adverse effects documented

The effect of many drugs used to treat cancer also reflects a cumulative actioneg, the extent of binding of a drug to DNA is proportional to drug concentration and is usually irreversible

Intramuscular These injections typically have better results and inject the medicine directly into the muscle, which is then absorbed by the surrounding muscle immediately

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To match the peak steady-state concentration, the loading dose can be calculated from equation (13): TARGET CONCENTRATION INTERVENTION: APPLICATION OF PHARMACOKINETICS & PHARMACODYNAMICS TO DOSE INDIVIDUALIZATION The basic principles outlined above can be applied to the interpretation of clinical drug concentration measurements on the basis of three major pharmacokinetic variables: absorption, clearance, and volume of distribution (and the derived variable, half-life)