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Recent evidence indicates that iron dyshomeostasis and ferroptotic processes directly compromise BBB integrity, thereby facilitating the influx of pathological factors and promoting neuroinflammatory propagation, which accelerates the progression of Alzheimers disease (AD) (Xu et al., 2024

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Younger mice exposed to a prolonged high-fat diet and hyperglycemia showed increased insulin, glucose, and frequency of activated microglia in the dentate gyrus of the hippocampal formation and cornu ammonis of the hippocampus (Yao et al., 2023)

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