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This duality complicates the clinical translation, as inhibiting autophagy may improve chemotherapy sensitivity in certain cancers but risk damaging healthy tissues in others

Adipose tissue metabolism and inflammation are differently affected by weight loss in obese mice due to either a high-fat diet restriction or change to a low-fat diet

In conclusion, hm 5 C-modified mRNA promotes protein translation (up to 100-fold) compared to unmodified mRNA, and its combination with other analogues represents a promising approach for RNA therapeutics

CAT, antioxidant enzyme catalase