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Moreover, reducing drug dosage still achieved significant cytotoxic effects

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Conclusion: Data suggest a nonlinear decrease in mortality risk as circulating 25(OH)D increases, with ."(17) optimal concentrations 75-87.5 nmol/L [30-46 ng/mL] You can see this in their Figure, which is nominally U-shaped, with the sweet spot at ~31 ng/mL, although the CIs don't rule out the possibility that mortality merely FLATTENS at 31 ng/mL and above, rather than reaching a true trough there with risks getting worse at higher values: Caption: "Summary nonlinear dose-response relation (dotted lines: 95% CI) from the best-fitting random-effects model, between an increase in the concentration of 25(OH)D (ng/mL) with respect to reference values and overall mortality RR