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The dose is paramount

Georges Naasan, an associate professor of neurology and medical director for the division of Behavioral Neurology and Neuropsychiatry at Mount Sinai, said he was concerned about the potentially increased rate of ARIA, both ARIA-E and ARIA-H. This would require appropriate counseling with patients about the increased risk, he told CNN by email

In a small clinical trial, tumors shrank in 6 of 11 people with ASPS treated with a combination of the immune checkpoint inhibitor pembrolizumab (Keytruda) and the targeted drug axitinib (Inlyta)

Kannan KK, Ramanadham M, Jones TA

This blueprint is rapidly being emulated by other combination strategies that seek to deliver multidimensional, disease-modifying benefits for complex metabolic disorders