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Okeke EB, Louttit C, Fry C, Najafabadi AH, Han K, Nemzek J, et al

Defined by hyperandrogenism, ovulatory dysfunction, insulin resistance, and chronic low-grade inflammation, PCOS, a common endocrine disorder in reproductive aged women causes irregular periods, infertility, excess androgens which collectively contributes toward long-term risks for serious conditions like type 2 diabetes, cardiovascular diseases, sleep apnea, depression, endometrial cancer and other reproductive complications underscoring the need for a comprehensive, multifaceted management strategy ( Figure 1 )

Among them, liver metastasis is the most common CRC, and the rate of liver metastasis can over 50%

Heavy metals primarily impair antioxidant defenses by interacting with sulfhydryl groups in non-enzymatic antioxidant systems, forming organometallic complexes that reduce the bodys antioxidant capacity