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Initially, they polarize toward an M1 phenotype, secreting TNF-, IL-12, and reactive nitrogen species that sustain inflammation and contribute to tissue injury

Dendritic cells and cancer immunity

doi: 10.1182/blood-2007-04-081703 40 MortensenM.FergusonD

Another study reported that asiaticoside accelerated wound healing and collagen maturation and reduced scar formation in scalded rats by affecting the expression of heat shock protein 47

5.2 Inflammatory signaling and immune activation Regulated cell death pathways, including nonlytic apoptosis and lytic forms such as necroptosis, pyroptosis, and ferroptosis, release DAMPs that trigger sterile inflammation in the lung (153, 154)