glutathione peroxidase type - Proteases Figure 1 from Comparing glutathione

potentially fatal disturbances of cardiac conduction (widening of QRS), arrhythmias & seizures due to Na channel block (cardiac & CNS) Pharmacokinetics: PO, metabolized in the liver (P450 - 2D6)

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Cytoplasmic iron can enter the mitochondria from the cytoplasm through Mfrn2 and the mitochondrial calcium uniporter (MCU) [56]

Several studies using reconstituted ISC machineries of mouse, human, yeast, and bacteria have reported a key function of frataxin in this process, but most of these reconstructions used incomplete ISC machineries, lacking FDX2 and FDXR (Figure 2B, red chart), which has led to a misinterpretation of the functional role of frataxin