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Szyller et al., 2022)

10.3389/fendo.2023.1139858 [DOI] [PMC free article] [PubMed] [Google Scholar] Shen H., Xu X., Fu Z., Xu C., Wang Y

23,49 This severe dysbiosis leads to the collapse of gut barrier function, allowing bacteria and their products (such as LPS and ammonia) to translocate to the portal vein and systemic circulation, directly driving the occurrence of fatal complications such as HE and spontaneous bacterial peritonitis (SBP)

To address this challenge, advanced DDS have been developed to enhance its bioavailability, stability, and therapeutic efficacy

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