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Bardoxolone methyl is a semi-synthetic triterpenoid that is known to activate the Nrf2 signaling pathway

In contrast, there was no significant decrease in the serum GSH/GSSG ratio or increase in carbonyl content of serum proteins

Opioid-induced esophageal dysfunction (OIED): Cases of OIED have been reported in patients taking opioids, and may occur more frequently in patients taking higher doses of opioid, and/or in patients taking opioids longer term [see WARNINGS]

15 It is recommended to initiate at 50% of the usual dose in mild-to-moderate hepatic impairment and avoid use in severe hepatic impairment

Human Burkitt B lymphocytes require an adequate arginine concentration for proliferation and maturation