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It should also be noted that RBCs lack other NADPH-producing enzymes, and any loss of NADPH cannot be compensated by other pathways

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This work was supported by the Burroughs Wellcome Fund Vanderbilt SCRIPS Faculty Scholar Award (PI: Naira Baregamian) and the National Cancer Institute/Vanderbilt-Ingram Cancer Center Multi-Tier Developmental Support Grant (P30CA068485) (PI: Naira Baregamian)

The enzyme xanthine dehydrogenase (XDH), normally producing NADH, is converted to its oxidase form (XO) through calcium-activated proteases or oxidative modification (Kusano et al., 2023)