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2.4.1.1 Development of the detection algorithm While the Average PN algorithm had shown promise in previous clinical trials (Mrachacz-Kersting et al., 2016, 2019), it was not considered a BCI system (Mrachacz-Kersting et al., 2021), as it employed a predetermined timing in an open-loop manner to trigger stimulation during the neurofeedback sessions rather than real-time detection

(left) UMAP of NT and perturbed cells, colored by perturbation condition

10.1038/s41598-019-42130-z Sci Rep

The science looked promising and the safety profile seemed reasonable