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In agreement with these data, inactivation of this pathway in astrocytes reduces MAFG signaling, methylation of target genes and expression of proinflammatory pathways resulting in clinical improvement in EAE (130)

Rather, Epitalon may act like a molecular locksmith, loosening tightly wound regions of DNA, allowing previously silenced genes, such as those involved in antioxidant defenses or DNA repair, to reawaken

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& Rossi, L