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These observations created the initial hypothesis of prominent astrogliosis as an early event in the time course of pathology in the AD continuum 354

In a dedicated analysis of data from the United States Food and Drug Administrations Adverse Event Reporting System [76], the rate of rhabdomyolysis was 0.58 cases per million prescriptions for fenofibrate combined with any statin other than cerivastatin (a statin with a high risk of rhabdomyolysis that was taken out of the market), as compared to 8.6 cases per million prescriptions for gemfibrozil in the same combination

Similarly, resistance to cisplatin can occur because of changes in processes (drug uptake, drug efflux, and/or intracellular drug sequestration) that prevent adequate levels of the drug reaching its DNA target, or by enhanced activity of processes that repair the DNA after it has been modified by the drug (Fig