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Many researchers have focused on investigating the impact of ICB treatment on the interactions between immune cells and cancer cells in the tumor microenvironment (170, 183185), including the tertiary lymphoid structures (186190), as well as the T cell phenotypes in the peripheral circulation (191197)

Methionine and the glutathione pathway Methionine serves as a precursor for cysteine and, subsequently, for glutathione, one of the most important intracellular antioxidants

Methionine is essential for the formation of healthy collagen used to form skin, nails, and connective tissue, and helps reduce the level of inflammatory histamines in the body

This auto-oxidation process generates toxic reactive oxygen species (ROS), quinones, and free radicals that damage intracellular organelles, deplete cellular glutathione, and ultimately trigger apoptotic cell death (Lohr et al., 2014

Saunders College Publishing, Fort Worth