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Freezing a liquid solution causes sharp ice crystals to form

Hence, it is logical to hypothesize that masking of the terminal NH 2 group by making a labile chemical derivative of INH, i.e., a derivative which can release INH back when exposed to biofluid in gut or blood (owing to hydrolytic activity of esterase/amidase) can limit known metabolic biotransformations of INH (Figure 6)

We posit that the integration of pharmacological treatment with rehabilitation may yield synergistic effects, accelerating cognitive recovery and functional gains (4951)

Melittin, a small protein consisting of 26 amino acid residues, appears to downregulate phospholipase A2 (PLA2), cyclooxygenase (COX-2), and TNF- expression while reducing levels of IL-1, IL-6, nitric oxide (NO), and reactive oxygen species (ROS) (45)

The profiling was also performed using the TMT-LC/LC-MS/MS method 46,47,48,49 , with an additional step of phosphopeptide enrichment to improve the phosphoproteome coverage 55 (Supplementary Fig