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Abbreviations AD: Atopic dermatitis ATP: Adenosine triphosphate CINDUs: Chronic inducible urticarias CCL2: C-C motif chemokine ligand 2 COLD-CE: Comprehensive evaluation of cold urticaria and other cold-induced reactions, a study of the GA 2 LEN UCARE network COVID-19: Coronavirus disease-2019 EAACI: European Academy of Allergy and Clinical Immunology ED: Emergency department EIA: Exercise-induced anaphylaxis FDEIA: Food-dependent exercise-induced anaphylaxis HDAC: Histone deacetylase HIF-1: Hypoxia-inducible factor 1-alpha HR: Histamine release ICU: Intensive care unit IgE: Immunoglobulin E K m : Michaelis constant LAD2 cells: The Laboratory of Allergic Diseases mast cell line LDH: Lactate dehydrogenase MC: Mast cell MCT1: Monocarboxylate transporter 1 MRGPRX2: Mas-related G protein-coupled receptor X2 mTOR: Mammalian target of rapamycin NAD: Nicotinamide adenine dinucleotide NADH: Nicotinamide adenine dinucleotide hydrogen NRS: Numeric rating scale ROC: Receiver operating characteristic POEM: Patient-oriented eczema measure TLR: Toll-like receptor UCARE: GA 2 LEN network of urticaria centres of reference and excellence VEGF: Vascular endothelial growth factor References Bartnikas LM, Sicherer SH

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