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2024), the ferroptotic cell death was confirmed by the reduced expression of GSH, GPX-4, ferritin heavy chain (FTH) and SQSTM1, while nuclear receptor coactivator4 (NCOA4) and LC3II/I were markedly upregulated

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It is reported that PGC-1 affects cellular oxidative capacity and fatty acid oxidation through the regulation of mitochondrial and nuclear genes 13,14

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The pharmacokinetic advantage is significant: systemic bioavailability of intranasal peptides is typically 1020%, but CNS bioavailability can reach 3060% because the compound travels directly along nerve sheaths into cerebrospinal fluid