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10.1126/science.aau2095 13

Many users notice diminishing effects after 3 to 5 months of continuous use due to receptor desensitization

There are exactly two clinical trials for that peptide in the federal governments clinical trials database

However, when symptoms persist but exacerbate over weeks or months, it could indicate a relatively rare condition named SIRVA, an acronym for Shoulder Injury Related to Vaccine Administration