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helped with the writing of the original manuscript

This remains an actively moving area, however: on February 27, 2026, the HHS Secretary publicly announced an intent to move roughly 14 of the 19 Category 2-listed peptides, reportedly including ipamorelin and CJC-1295, back toward Category 1 status, and multiple industry and legal-news outlets reported further FDA action in the following months easing Category 2-related restrictions on this group of peptides

J Biol Chem 289:3523735245

doi: 10.1016/j.tube.2018.04.009 35 RandallPJHsuNJQuesniauxVRyffelBJacobsM

The lysine residue's positive charge facilitates interaction with glycosaminoglycans and negatively charged phospholipids in cellular membranes, enhancing uptake efficiency