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All E3 ligases have the unique function of linking a specific E2 to a target protein, facilitating the transfer of ubiquitin from E2 enzymes to their substrates, sometimes via a covalent E3 ubiquitin thioester intermediate (42)

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The song manages to be specific in its approach to Gagas use of alcohol to numb her pain the chorus hopeful refrain of Id rather be dry, but at least Im alive also refers to Gaga being thankful shes still here, even if she isnt sober yet while also leaving enough room for fans to insert their own respective traumas, or to simply enjoy the ride unburdened

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