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Some patients who combine tirzepatide with sustained lifestyle changesconsistent exercise, whole-food nutrition, sleep optimization, and stress managementmay be candidates for a 'drug holiday' or gradual dose reduction under medical supervision

The isolated effector domain exists primarily as a monomer in solution, but forms a hexamer ring in crystal via tandem association between adjacent protomers, and two hexamers are linked by the crystallographic 2-fold symmetry to generate a dodecamer [323]

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