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It is observed that infants, children, adolescents, and women of reproductive age are also at high risk of deficiency

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It has to be mentioned that KO mice for IGF-1 gene are not viable and studies in such mice have to be done in the first days of life, and thus results are not very conclusive as metabolism is not properly established at this stage [129, 228]

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Requiring daily administration to sustain NNMT inhibition