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Throughout the day, adenosine levels gradually increase in the brain, leading to a sense of tiredness and the eventual need for sleep

However, despite its growing application in causal inference, Mendelian randomisation studies are subject to several inherent limitations that must be critically considered when interpreting their findings

Kosiek, W., Rauk, Z., Szulc, P., Cichy, A., Rugie, M., Chwiej, J., Janeczko, K., & Setkowicz, Z

( There is debate on whether hypertension and/or hypotension have a relationship with migraine (Hagen et al., 2003